The International Conference YENBIOCON 2025, jointly organized by the Department of Biochemistry, Yenepoya Medical College, and the Division of Data Analytics, Bioinformatics and Structural Biology (DABS), Yenepoya Research Centre, Yenepoya (Deemed to be University) will be held on 18 th –19 th December 2025, in Mangalore, Karnataka, India. With the theme “Next-Generation Sequencing and Clinical Genetics”, the conference aims to serve as a vibrant platform for scientists, clinicians, academicians, students, and industry professionals to share knowledge and explore the latest developments in genomics, molecular medicine, and clinical applications. The conference will feature a series of keynote addresses and invited talks by eminent experts, covering critical topics such as the role of genomics in precision medicine, the application of Next-Generation Sequencing (NGS) in oncology, advances in gene expression studies, and the significance of Indian ancestral variation in clinical genetics. In addition, scientific sessions will include oral and e-poster presentations, providing opportunities for undergraduates, postgraduates, doctoral scholars, and faculty to present their research findings, exchange ideas, and receive constructive feedback from peers and experts. One of the most exciting highlights is the hands-on workshop on NGS. This session is designed to provide participants with practical training on sequencing methodologies, data management, and result interpretation. By engaging directly with the tools and techniques of NGS, participants will acquire skills that are highly relevant to both clinical diagnostics and advanced research. Attending YENBIOCON 2025 offers several benefits: exposure to cutting-edge scientific advancements, networking with leading experts and fellow researchers, skill-building through experiential learning, and potential opportunities for future collaborations. For students and early-career researchers, it also provides an invaluable platform to enhance presentation skills and gain visibility for their work. YENBIOCON 2025 promises to be a knowledge-enriching experience, bridging the gap between emerging technologies and real-world healthcare applications.